![]() ![]() In the heart, H2 receptors are important in controlling the rhythm. When histamine activates the H2 receptors in the stomach, acid is released. ![]() Activating the H1 receptors causes allergy-type symptoms such as itching, swelling, vasodilation, nose running, and skin reactions. These receptors are found in smooth muscle, endothelial cells (lining the blood vessels), central nervous system, cardiac muscle, and mast cells. How can one molecule, histamine, cause such different actions?įour different histamine receptors cause histamine actions: Histamine was initially linked to heart arrhythmias, according to early research. Histamine is a signaling molecule that causes an action to take place depending on which receptor it binds to.įor more than a century, it has been known that histamine causes the heart rate to increase and heart contractions to be more forceful. But there is much more to the histamine story than just watery eyes and a runny nose during allergy season. Histamine is most commonly associated with allergic reactions, such as when your nose runs due to pollen allergies in the spring. High levels of biogenic amines can cause negative effects (diarrhea, food poisoning, vomiting, sweating, or tachycardia) if consumed or produced in excess. ![]() Biogenic amines are required in just the right amount and in the right tissues. Other biogenic amines include tyramine, cadaverine, and putrescine. It is produced by converting the amino acid histidine into histamine through a decarboxylation reaction. Histamine is a biogenic amine produced by your cells, by the gut microbiome, and also found in foods. Let’s start with an explanation of histamine and its roles in the body. I’m going to explore the research linking histamine, mast cells, and the spike protein. Histamine, Heart Rhythm, Spike Protein, Mast Cells – oh my! Lifehacks Blocking histamine and mast cell degranulation.Other symptoms, such as nerve issues and tinnitus.Polyethylene Glycol – Allergic reactions?.Mast Cells Immune response to SARS-CoV-2 and Spike Protein.What does all of this have to do with the SARS-CoV-2 spike protein?.Histamine, Heart Rhythm, Spike Protein, Mast Cells – oh my!.Case reports highlight several individual cases, but I am not finding longitudinal studies. Statistics are harder to come by for heart palpitations or tachycardia after the mRNA vaccines. In December 2021, a meta-analysis showed that about 20% of people with long Covid continued to have heart palpitations. ![]() Several research papers have studied the link between long Covid and heart rhythm disorders. Although some people have naturally higher or lower heart rates and blood pressure, most of us who are still kicking today have a heart rhythm that stays in a normal range. We expect it to carry on in a regular fashion, not too fast and not too slow. We take the rhythm of our hearts for granted. It’s good that there isn’t heart damage, but it is frustrating for both the doctors and patients to have an unknown cause. These anecdotal stories often wind up with… The cardiologist says nothing is really wrong, and now I have a prescription for a blood pressure medicine. Some people end up in the ER or urgent care others head to the cardiologist to get their heart thoroughly checked out with CT scans, stress tests, and holter monitors. For others, the tachycardia just happens when they stand up.Īccompanying these heart rhythm issues are a range of symptoms, including dizziness, tinnitus (ringing in the ears), chest pains, fatigue, muscle twitches, and just not feeling right. The racing heart rate, or tachycardia, seems to happen randomly for some people – while driving, sitting around at home, or when exercising. Their heart rhythm issues are described as palpitations, PVCs, skipped beats, or a-fib. Let me set the stage: The stories that I’ve heard from friends, Genetic Lifehacks members, and via many online anecdotes often go like this:Īfter covid and/or after the mRNA vaccines, the individual starts having heart palpitations and a racing heart. Instead, I’m going to pull together recent research studies in an effort to puzzle out a cause of some of the constellation of issues surrounding long Covid and/or post-vaccine. This article is a departure from my usual writings on how genetic variants interact with foods or health issues. ![]()
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